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Drug Delivery Instrumentation

Amersham Biosciences (now GE Healthcare) LEADseeker Multimodality Imaging System is a completely automated system designed to include fluorescent assay screening. The LEADseeker Multimodality Imager includes an excitation light system consisting of a 150 W tungsten halogen lamp and ring light combined with automated excitation and emission filter changing facilities, enables up to six excitation wavelengths and four emission wavelengths to be selected.

The LEADseeker Multimodality Imager can function in three modes: as a manual system for assay development, in a stacker workstation mode where microplates are delivered from a stacker carousel to the imager, or as a fully automated system integrated with major robotics platforms for high-throughput screening (HTS) environments. Plates can be imaged in seconds and automation allows the processing of several hundred plates, or approximately 500 000 tests per day, using miniaturized screening formats.

Originally engaged as industrial designers we became project managers to convert the laboratory proof of principle prototype into a saleable instrument for the global pharmaceutical market.

We had a significant influence on inventory, cashflow and QA as a result of design thinking with new assembly methods and sub system testing. The team included optics designers, mechanical and electronic engineers and a small production group that built and tested production systems including 3 prototypes.

For more information please contact our
Healthcare team

T: +44 (0)1799 533200
E: healthcare@plextek.com

Ambulatory ECG Monitoring - Real time vital signs monitoring

Ambulatory ECG Monitoring

Challenge:
Our client wanted to develop a battery powered ambulatory device to obtain electrocardiogram (ECG) information from an adult patient. The technology would then transmit the ECG information to a server for data analysis. Their vision of monitoring vital signs of ambulatory patients in real-time and transmitting data via the Wireless Medical Telemetry System frequencies required consideration of multiple data analysis functions. Data recorded would need to indicate accurate readings of heart rate determination, R-wave detection, ECG filtering and arrhythmia recognition.

Approach:
The indoor wireless networks in hospitals, it was discovered, were inherently unreliable due to reflective equipment. Solid walls, beds and wards caused interference with existing band signals and this presented a significant challenge as complete reliability needed to be ensured when utilising the frequencies. The solution incorporated multiple antennas being installed to ensure communication with tele-packs. A new bespoke system was introduced including, radios, signal processing, software and a new secure band level for our technology. Plextek assisted with the development throughout, from concept to end manufacture.

Outcome:
The product has been approved by The Food and Drug Administration for use in the USA with one third of all US hospitals implementing the monitoring solution in practice. The bespoke system was inherently designed to facilitate the holistic healthcare approach by allowing multiple patients monitoring. Based on one device per patient, the band width allows for up to 189 patients to be monitored at any given time.

For more information please contact our Healthcare team: T: +44 (0)1799 533200
E: healthcare@plextek.com

Ambulatory ECG Monitoring - Real time vital signs monitoring

Ambulatory ECG Monitoring

Challenge:
Our client wanted to develop a battery powered ambulatory device to obtain electrocardiogram (ECG) information from an adult patient. The technology would then transmit the ECG information to a server for data analysis. Their vision of monitoring vital signs of ambulatory patients in real-time and transmitting data via the Wireless Medical Telemetry System frequencies required consideration of multiple data analysis functions. Data recorded would need to indicate accurate readings of heart rate determination, R-wave detection, ECG filtering and arrhythmia recognition.

Approach:
The indoor wireless networks in hospitals, it was discovered, were inherently unreliable due to reflective equipment. Solid walls, beds and wards caused interference with existing band signals and this presented a significant challenge as complete reliability needed to be ensured when utilising the frequencies. The solution incorporated multiple antennas being installed to ensure communication with tele-packs. A new bespoke system was introduced including, radios, signal processing, software and a new secure band level for our technology. Plextek assisted with the development throughout, from concept to end manufacture.

Outcome:
The product has been approved by The Food and Drug Administration for use in the USA with one third of all US hospitals implementing the monitoring solution in practice. The bespoke system was inherently designed to facilitate the holistic healthcare approach by allowing multiple patients monitoring. Based on one device per patient, the band width allows for up to 189 patients to be monitored at any given time.

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For more information please contact our Healthcare team:
T: +44 (0)1799 533200
E: healthcare@plextek.com

Contains public sector information licensed under the Open Government Licence v3.0

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